2654 Ron (C81H9) Rabbit mAb #2654

"上海博耀生物销售Ron (C81H9) Rabbit mAb #2654，CST原装品质，价格优惠，订购Ron (C81H9) Rabbit mAb #2654，详情请咨询销售人

"上海博耀生物销售Ron (C81H9) Rabbit mAb #2654，CST原装品质，价格优惠，订购Ron (C81H9) Rabbit mAb #2654，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Ron (C81H9) Rabbit mAb #2654
货号：2654
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2654S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H	Endogenous	145 and 150 kDa	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Ron (C81H9) Rabbit mAb detects endogenous levels of the β chain of Ron protein. This antibody does not cross-react with other family members.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys624 of human Ron.
抗体背景：

Ron is a member of the Met protooncogene family of receptor tyrosine kinases, which also includes Stk, c-Met, and c-Sea. The functional Ron is a heterodimer composed of a 40 kDa α chain and a 150 kDa β chain. Ron is initially synthesized in the cells as a single-chain, pro-Ron precursor that is cleaved into the two active chains. The α chain is completely extracellular, whereas the β chain traverses the cell membrane and contains the intracellular tyrosine kinase and regulatory elements (1,2). Ron mediates multiple signaling cascades that involve cell motility, adhesion, proliferation, and apoptosis. The signaling pathways activated downstream of Ron include the ras/mitogen-activated protein kinase (MAPK), phosphatidyl inositol-3 kinase (PI3K)/Akt, and focal adhesion kinase (FAK) pathways. Ron activation can also significantly increase c-Src activity, a signaling intermediate involved in cell cycle progression, motility, angiogenesis and survival (3,4). The function of Ron has been shown to be important for embryological development as well as implicated in the progression and metastasis of tumors (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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