2653 Stat4 (C46B10) Rabbit mAb #2653

"上海博耀生物销售Stat4 (C46B10) Rabbit mAb #2653，CST原装品质，价格优惠，订购Stat4 (C46B10) Rabbit mAb #2653，详情请咨询

"上海博耀生物销售Stat4 (C46B10) Rabbit mAb #2653，CST原装品质，价格优惠，订购Stat4 (C46B10) Rabbit mAb #2653，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Stat4 (C46B10) Rabbit mAb #2653
货号：2653
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2653S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W ChIP	H M R	Endogenous	81	Rabbit IgG

Applications Key:  W=Western Blotting  ChIP=Chromatin IP
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Stat4 (C46B10) Rabbit mAb detects endogenous levels of total Stat4 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys151 of Stat4.
抗体背景：

The Jak-Stat signaling pathway is utilized by a large number of cytokines, growth factors, and hormones (1). Receptor-mediated tyrosine phosphorylation of Jak family members triggers phosphorylation of Stat proteins, resulting in their nuclear translocation, binding to specific DNA elements, and subsequent activation of transcription. The remarkable range and specificity of responses regulated by the Stats is determined, in part, by the tissue-specific expression of different cytokine receptors, Jaks, and Stats, as well as by the combinatorial coupling of various Stat members to different receptors (2). Stat4 is predominantly expressed in the spleen, thymus, and testis and has been most extensively investigated as the mediator of IL-12 responses (3-8). Activation of Stat4 is associated with phosphorylation at Tyr693 (9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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