2620 Jagged1 (28H8) Rabbit mAb #2620

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"上海博耀生物销售Jagged1 (28H8) Rabbit mAb #2620，CST原装品质，价格优惠，订购Jagged1 (28H8) Rabbit mAb #2620，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Jagged1 (28H8) Rabbit mAb #2620
货号：2620
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2620S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M (R)	Endogenous	180	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Jagged1 (28H8) Rabbit mAb detects endogenous levels of total Jagged1 protein. It does not cross-react with Jagged2.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Glu1140 (intracellular region) of human Jagged1.
抗体背景：

Notch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (Delta, Serrate, Lag2) proteins of single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch (1,2). Five DSL proteins have been identified in mammals: Jagged1, Jagged2, Delta-like (DLL) 1, 3 and 4 (3). Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the γ-secretase complex. The intracellular domain of Notch is released and then translocates to the nucleus where it activates transcription. Notch ligands may also be processed in a way similiar to Notch, suggesting a bi-directional signaling through receptor-ligand interactions (4-6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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