2603 AMPKα (23A3) Rabbit mAb #2603

"上海博耀生物销售AMPKα (23A3) Rabbit mAb #2603，CST原装品质，价格优惠，订购AMPKα (23A3) Rabbit mAb #2603，详情请咨询销

"上海博耀生物销售AMPKα (23A3) Rabbit mAb #2603，CST原装品质，价格优惠，订购AMPKα (23A3) Rabbit mAb #2603，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：AMPKα (23A3) Rabbit mAb #2603
货号：2603
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2603P	40 ul (4 western blots)	询价
2603S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R Mk	Endogenous	62	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： AMPKα (23A3) Rabbit mAb detects endogenous levels of total AMPKα protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the amino-terminal sequence of human AMPKα.
抗体背景：

AMP-activated protein kinase (AMPK) is highly conserved from yeast to plants and animals and plays a key role in the regulation of energy homeostasis (1). AMPK is a heterotrimeric complex composed of a catalytic α subunit and regulatory β and γ subunits, each of which is encoded by two or three distinct genes (α1, 2; β1, 2; γ1, 2, 3) (2). The kinase is activated by an elevated AMP/ATP ratio due to cellular and environmental stress, such as heat shock, hypoxia, and ischemia (1). The tumor suppressor LKB1, in association with accessory proteins STRAD and MO25, phosphorylates AMPKα at Thr172 in the activation loop, and this phosphorylation is required for AMPK activation (3-5). AMPKα is also phosphorylated at Thr258 and Ser485 (for α1; Ser491 for α2). The upstream kinase and the biological significance of these phosphorylation events have yet to be elucidated (6). The β1 subunit is post-translationally modified by myristoylation and multi-site phosphorylation including Ser24/25, Ser96, Ser101, Ser108, and Ser182 (6,7). Phosphorylation at Ser108 of the β1 subunit seems to be required for the activation of AMPK enzyme, while phosphorylation at Ser24/25 and Ser182 affects AMPK localization (7). Several mutations in AMPKγ subunits have been identified, most of which are located in the putative AMP/ATP binding sites (CBS or Bateman domains). Mutations at these sites lead to reduction of AMPK activity and cause glycogen accumulation in heart or skeletal muscle (1,2). Accumulating evidence indicates that AMPK not only regulates the metabolism of fatty acids and glycogen, but also modulates protein synthesis and cell growth through EF2 and TSC2/mTOR pathways, as well as blood flow via eNOS/nNOS (1).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-alpha 1 Spectrin/Spectrin α血影蛋白/收缩蛋白抗体
ab103687/Anti-Cytokeratin 7 antibody
ab103133/Anti-GBE1 antibody
ab101478/Anti-Glypican 3 antibody
Anti-HSP27/HspB1/HSP25热休克蛋白27抗体
Anti-Cyclooxygenase 2/COX2前列腺素过氧化物合成酶2抗体
ab103655/Anti-CCDC94 antibody
Anti-Desmin/DES结蛋白抗体
ab103577/Anti-FGF1 antibody
Anti-HHV8/ORF50人类疱疹病毒8抗体
ab10168/Anti-Centaurin alpha 1 antibody
Anti-PCDHA4原钙粘附蛋白α4抗体
Anti-Collagen IⅠ型胶原抗体
ab1015/Anti-Factor V Heavy Chain antibody
Anti-ACE1/CD143血管紧张素转换酶ACE1抗体
Anti-ABCG2/CD338三磷酸腺苷结合转运蛋白G超家族成员2抗体"
本页产品地址：http://www.geilan.com/sell/show-3243657.html