2588 DLL1 Antibody #2588

"上海博耀生物销售DLL1 Antibody #2588，CST原装品质，价格优惠，订购DLL1 Antibody #2588，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售DLL1 Antibody #2588，CST原装品质，价格优惠，订购DLL1 Antibody #2588，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：DLL1 Antibody #2588
货号：2588
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2588S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	R (H)	Transfected Only	82	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： DLL1 Antibody detects transfected levels of DLL1. It does not recognize transfected levels of rat DLL3 and human DLL4.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a region surrounding residue Ala627 of human DLL1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Notch signaling is activated upon engagement of the Notch receptor with its ligands, the DSL (Delta, Serrate, Lag2) proteins of single-pass type I membrane proteins. The DSL proteins contain multiple EGF-like repeats and a DSL domain that is required for binding to Notch (1,2). Five DSL proteins have been identified in mammals: Jagged1, Jagged2, Delta-like (DLL) 1, 3 and 4 (3). Ligand binding to the Notch receptor results in two sequential proteolytic cleavages of the receptor by the ADAM protease and the γ-secretase complex. The intracellular domain of Notch is released and then translocates to the nucleus where it activates transcription. Notch ligands may also be processed in a way similiar to Notch, suggesting a bi-directional signaling through receptor-ligand interactions (4-6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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