2578 Histone H2A Antibody II #2578

"上海博耀生物销售Histone H2A Antibody II #2578，CST原装品质，价格优惠，订购Histone H2A Antibody II #2578，详情请咨询销售

"上海博耀生物销售Histone H2A Antibody II #2578，CST原装品质，价格优惠，订购Histone H2A Antibody II #2578，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Histone H2A Antibody II #2578
货号：2578
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2578P	40 ul (4 western blots)	询价
2578S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP IHC-P	H M R Mk (C) (X)	Endogenous	14	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  C=Chicken  X=Xenopus
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Histone H2A Antibody II detects endogenous levels of total histone H2A protein, but not cross-react with other histones.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide designed based on the region around Threonine 77 of human Histone H2A sequence. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin (1). The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination (2-5). These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression (6). In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 (4,7). Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms (2,3). Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis (8-10). Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase (11).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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