2560 LRP6 (C5C7) Rabbit mAb #2560

"上海博耀生物销售LRP6 (C5C7) Rabbit mAb #2560，CST原装品质，价格优惠，订购LRP6 (C5C7) Rabbit mAb #2560，详情请咨询销售人

"上海博耀生物销售LRP6 (C5C7) Rabbit mAb #2560，CST原装品质，价格优惠，订购LRP6 (C5C7) Rabbit mAb #2560，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：LRP6 (C5C7) Rabbit mAb #2560
货号：2560
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2560P	40 ul (4 western blots)	询价
2560S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H R	Endogenous	180, 210 kDa	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： LRP6 (C5C7) Rabbit mAb detects endogenous levels of total LRP6 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Met1409 of human LRP6.
抗体背景：

LRP5 and LRP6 are single-pass transmembrane proteins belonging to the low-density lipoprotein receptor (LDLR)-related protein family. Unlike other members of the LDLR family, LRP5 and LRP6 have four EGF and three LDLR repeats in the extracellular domain, and proline-rich motifs in the cytoplasmic domain (1). They function as co-receptors for Wnt and are required for the canonical Wnt/β-catenin signaling pathway (2,3). LRP5 and LRP6 are highly homologous and have redundant roles during development (4,5). The activity of LRP5 and LRP6 can be inhibited by the binding of some members of the Dickkopf (DKK) family of proteins (6,7). Upon stimulation with Wnt, LRP6 is phosphorylated at multiple sites including Thr1479, Ser1490, and Thr1493 by kinases such as GSK-3 and CK1 (8-10). Phosphorylated LRP6 recruits axin to the membrane and presumably activates β-catenin signaling (8-10).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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