2558 Phospho-p57 Kip2 (Thr310) Antibody #2558

"上海博耀生物销售Phospho-p57 Kip2 (Thr310) Antibody #2558，CST原装品质，价格优惠，订购Phospho-p57 Kip2 (Thr310) Antibody

"上海博耀生物销售Phospho-p57 Kip2 (Thr310) Antibody #2558，CST原装品质，价格优惠，订购Phospho-p57 Kip2 (Thr310) Antibody #2558，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-p57 Kip2 (Thr310) Antibody #2558
货号：2558
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2558S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IF-IC	H	Endogenous	57	Rabbit

Applications Key:  W=Western Blotting  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-p57 Kip2 (Thr310) Antibody detects endogenous levels of p57 Kip2 only when phosphorylated at threonine 310. This antibody may cross-react with p27 Kip1 when phosphorylated at Thr187.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Thr310 of human p57 Kip2. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

p27 Kip1 is a member of the Cip/Kip family of cyclin-dependent kinase inhibitors. Like its relatives, p57 Kip2 and p21 Waf1/Cip1, the ability to enforce the G1 restriction point is derived from its inhibitory binding to CDK2/cyclin E and other CDK/cyclin complexes. Expression levels of p27 are upregulated in quiescent cells and in cells treated with cAMP or other negative cell cycle regulators. Downregulation of p27 can be induced by treatment with interleukin-2 or other mitogens; this involves phosphorylation of p27 and its degradation by the ubiquitin-proteasome pathway (1-4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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