2546 CDK2 (78B2) Rabbit mAb #2546

"上海博耀生物销售CDK2 (78B2) Rabbit mAb #2546，CST原装品质，价格优惠，订购CDK2 (78B2) Rabbit mAb #2546，详情请咨询销售人

"上海博耀生物销售CDK2 (78B2) Rabbit mAb #2546，CST原装品质，价格优惠，订购CDK2 (78B2) Rabbit mAb #2546，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：CDK2 (78B2) Rabbit mAb #2546
货号：2546
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2546P	40 ul (4 western blots)	询价
2546S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP F	H M R Mk	Endogenous	33	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  F=Flow Cytometry
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： CDK2 (78B2) Rabbit mAb detects endogenous levels of total CDK2 protein. The antibody does not cross-react with other CDKs.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues of human CDK2 .
抗体背景：

Cyclin-dependent kinase 2 (p33CDK2) is an important component of the cell cycle machinery. Like p34cdc2, kinase activity is regulated by phosphorylation state as well as association with a cyclin subunit and a CDK inhibitor. Inhibitory phosphorylation occurs on Thr14 and Tyr15 (1). Inhibition of CDK2-cyclin complexes can also be attributed to association with p27 Kip1 and p21 Waf1/Cip1 (2). Activation of CDK2 complexes requires dephosphorylation of Thr14 and Tyr15 by cdc25 phosphatase and phosphorylation of Thr160 (3), which is mediated by CAK, a complex of CDK7 and cyclin H (4). CDK2/cyclin E kinase activity is important for the G1 to S transition and phosphorylation of the Rb protein. During S-phase, active CDK2/cyclin A complexes predominate and phosphorylate E2F and the active CDK2 complex persists in the nucleus throughout G2 (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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