2545 HDAC2 Antibody (IP Preferred) #2545

"上海博耀生物销售HDAC2 Antibody (IP Preferred) #2545，CST原装品质，价格优惠，订购HDAC2 Antibody (IP Preferred) #2545，详

"上海博耀生物销售HDAC2 Antibody (IP Preferred) #2545，CST原装品质，价格优惠，订购HDAC2 Antibody (IP Preferred) #2545，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：HDAC2 Antibody (IP Preferred) #2545
货号：2545
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2545S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M Mk	Endogenous	60	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： HDAC2 Antibody (IP Preferred) detects endogenous levels of total HDAC2 protein and is the preferred antibody for immunoprecipitation. The antibody does not cross-react with other HDAC proteins.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of the human HDAC2 protein. Antibodies are purified by peptide affinity chromatography.
抗体背景：

Acetylation of the histone tail causes chromatin to adopt an "open" conformation, allowing increased accessibility of transcription factors to DNA. The identification of histone acetyltransferases (HATs) and their large multiprotein complexes has yielded important insights into how these enzymes regulate transcription (1,2). HAT complexes interact with sequence-specific activator proteins to target specific genes. In addition to histones, HATs can acetylate nonhistone proteins, suggesting multiple roles for these enzymes (3). In contrast, histone deacetylation promotes a "closed" chromatin conformation and typically leads to repression of gene activity (4). Mammalian histone deacetylases can be divided into three classes on the basis of their similarity to various yeast deacetylases (5). Class I proteins (HDACs 1, 2, 3, and 8) are related to the yeast Rpd3-like proteins, those in class II (HDACs 4, 5, 6, 7, 9, and 10) are related to yeast Hda1-like proteins, and class III proteins are related to the yeast protein Sir2. Inhibitors of HDAC activity are now being explored as potential therapeutic cancer agents (6,7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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