2544 Phospho-FGF Receptor 1 (Tyr766) (1E5) Rabbit mAb #2544

"上海博耀生物销售Phospho-FGF Receptor 1 (Tyr766) (1E5) Rabbit mAb #2544，CST原装品质，价格优惠，订购Phospho-FGF Receptor

"上海博耀生物销售Phospho-FGF Receptor 1 (Tyr766) (1E5) Rabbit mAb #2544，CST原装品质，价格优惠，订购Phospho-FGF Receptor 1 (Tyr766) (1E5) Rabbit mAb #2544，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-FGF Receptor 1 (Tyr766) (1E5) Rabbit mAb #2544
货号：2544
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2544S	100 ul (10 western blots)	询价
2544L	300 ul (30 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H	Transfected Only	120, 145	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-FGF Receptor 1 (Tyr766) (1E5) Rabbit mAb detects transfected levels of FGFR-1 only when phosphorylated at tyrosine 766. The antibody may cross-react with other FGFR family members and some activated protein tyrosine kinases including EGFR and insulin/IGF-I receptors.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr766 of human FGF receptor-1.
抗体背景：

Fibroblast growth factors (FGFs) produce mitogenic and angiogenic effects in target cells by signaling through cell surface receptor tyrosine kinases. There are four members of the FGF receptor family: FGFR1 (flg), FGFR2 (bek, KGFR), FGFR3, and FGFR4. Each receptor contains an extracellular ligand binding domain, a transmembrane domain, and a cytoplasmic kinase domain (1). Following ligand binding and dimerization, the receptors are phosphorylated at specific tyrosine residues (2). Seven tyrosine residues in the cytoplasmic tail of FGFR1 can be phosphorylated: Tyr463, 583, 585, 653, 654, 730, and 766. Tyr653 and Tyr654 are important for catalytic activity of activated FGFR and are essential for signaling (3). The other phosphorylated tyrosine residues may provide docking sites for downstream signaling components such as Crk and PLCγ (4,5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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