2542 Paxillin Antibody #2542

"上海博耀生物销售Paxillin Antibody #2542，CST原装品质，价格优惠，订购Paxillin Antibody #2542，详情请咨询销售人员！产品详

"上海博耀生物销售Paxillin Antibody #2542，CST原装品质，价格优惠，订购Paxillin Antibody #2542，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Paxillin Antibody #2542
货号：2542
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2542S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M R Mk B Pg	Endogenous	68	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  B=Bovine  Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Paxillin Antibody detects endogenous levels of total paxillin protein. The antibody does not cross-react with related proteins.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy-terminus of human paxillin. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Paxillin is a multidomain protein that localizes primarily to focal adhesion sites in the extracellular matrix (1). Paxillin is one of the key components of integrin signaling, and tyrosine phosphorylation of paxillin is required for integrin-mediated cytoskeletal reorganization (2). Paxillin is phosphorylated by another focal adhesion component, focal adhesion kinase (FAK), at Tyr118 (3,4). Phospho-FAK (Tyr118) may provide a docking site for recruitment of other signaling molecules to focal adhesions. It has been shown that the SH2 domain of Crk binds to the phosphorylated Tyr118 of paxillin (5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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