2523 Acetyl-Stat3 (Lys685) Antibody #2523

"上海博耀生物销售Acetyl-Stat3 (Lys685) Antibody #2523，CST原装品质，价格优惠，订购Acetyl-Stat3 (Lys685) Antibody #2523，

"上海博耀生物销售Acetyl-Stat3 (Lys685) Antibody #2523，CST原装品质，价格优惠，订购Acetyl-Stat3 (Lys685) Antibody #2523，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Acetyl-Stat3 (Lys685) Antibody #2523
货号：2523
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2523S	100 ul (10 western blots)	询价
2523L	300 ul (30 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H (M) (R)	Transfected Only	79, 86	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Acetyl-Stat3 (Lys685) Antibody detects transfected Stat3 when acetylated at lysine 685.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic acetylated peptide corresponding to residues surrounding lysine 685 of Stat3. Antibodies were purified by protein A and peptide affinity chromatography.
抗体背景：

The Stat3 transcription factor is an important signaling molecule for many cytokines and growth factor receptors (1) and is required for murine fetal development (2). Stat3 is constitutively activated in a number of human tumors (3,4) and possesses oncogenic potential (5) and anti-apoptotic activities (3). Stat3 is activated by phosphorylation at Tyr705, which induces dimerization, nuclear translocation, and DNA binding (6,7). Transcriptional activation seems to be regulated by phosphorylation at Ser727 through the MAPK or mTOR pathways (8,9). Stat3 isoform expression appears to reflect biological function as the relative expression levels of Stat3α (86 kDa) and Stat3β (79 kDa) depend on cell type, ligand exposure, or cell maturation stage (10). It is notable that Stat3β lacks the serine phosphorylation site within the carboxy-terminal transcriptional activation domain (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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