2520 SUFU (C54G2) Rabbit mAb #2520

"上海博耀生物销售SUFU (C54G2) Rabbit mAb #2520，CST原装品质，价格优惠，订购SUFU (C54G2) Rabbit mAb #2520，详情请咨询销售

"上海博耀生物销售SUFU (C54G2) Rabbit mAb #2520，CST原装品质，价格优惠，订购SUFU (C54G2) Rabbit mAb #2520，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：SUFU (C54G2) Rabbit mAb #2520
货号：2520
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2520S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M R Mk	Endogenous	54	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： SUFU (C54G2) Rabbit mAb detects endogenous level of total SUFU protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu458 of human SUFU.
抗体背景：

SUFU (Suppressor of Fused) was identified in Drosophila as a suppressor of the Fused (Fu) kinase that is essential for Hedgehog signaling during embryonic pattern formation (1). SUFU suppresses Hedgehog signaling by regulating the localization of the transcription factors Gli and Ci (2,3). In Drosophila, SUFU may also positively regulate Hedgehog signaling depending on SUFU protein levels and Hedgehog signal intensity (4). SUFU may function as a tumor suppressor as inactivation and loss of heterozygosity of SUFU is associated with human rhabdomyosarcomas and medulloblastomas (5,6). Deletion of SUFU in mice results in embryonic lethality, while heterozygotes exhibit developmental defects characteristic of basal cell nevus syndrome. This aberrant developmental pathway is attributed to ligand-independent activation of Hedgehog signaling (7). GSK-3β binds and phosphorylates SUFU in vitro and additional information predicts that GSK-3β may positively regulate Hedgehog signaling through modification of SUFU (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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