2519 TGF-β Receptor III Antibody #2519

"上海博耀生物销售TGF-β Receptor III Antibody #2519，CST原装品质，价格优惠，订购TGF-β Receptor III Antibody #2519，详情

"上海博耀生物销售TGF-β Receptor III Antibody #2519，CST原装品质，价格优惠，订购TGF-β Receptor III Antibody #2519，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：TGF-β Receptor III Antibody #2519
货号：2519
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2519S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M (R)	Endogenous	110	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： TGF-β Receptor III Antibody detects endogenous levels of the type III TGF-β receptor. This antibody does not cross-react with other family members at physiological conditions.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues in the extracellular domain of the type III TGF-β receptor. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Transforming growth factor-β (TGF-β) superfamily members are critical regulators of cell proliferation and differentiation, developmental patterning and morphogenesis, and disease pathogenesis (1-4). TGF-β elicits signaling through three cell surface receptors: type I (RI), type II (RII), and type III (RIII). Type I and type II receptors are serine/threonine kinases that form a heteromeric complex. In response to ligand binding, the type II receptors form a stable complex with the type I receptors allowing phosphorylation and activation of type I receptor kinases (5). The type III receptor, also known as betaglycan, is a transmembrane proteoglycan with a large extracellular domain that binds TGF-β with high affinity but lacks a cytoplasmic signaling domain (6,7). Expression of the type III receptor can regulate TGF-β signaling through presentation of the ligand to the signaling complex. The only known direct TGF-β signaling effectors are the Smad family proteins, which transduce signals from the cell surface directly to the nucleus to regulate target gene transcription (8,9).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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