2517 Phospho-Estrogen Receptor α (Ser104/106) Antibody #2517

"上海博耀生物销售Phospho-Estrogen Receptor α (Ser104/106) Antibody #2517，CST原装品质，价格优惠，订购Phospho-Estrogen R

"上海博耀生物销售Phospho-Estrogen Receptor α (Ser104/106) Antibody #2517，CST原装品质，价格优惠，订购Phospho-Estrogen Receptor α (Ser104/106) Antibody #2517，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-Estrogen Receptor α (Ser104/106) Antibody #2517
货号：2517
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2517P	40 ul (4 western blots)	询价
2517S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H (M)	Endogenous	66	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Estrogen Receptor alpha (Ser104/106) Antibody detects endogenous levels of ER alpha only when phosphorylated at Ser104/106. It does not cross-react with the phosphorylated ER isoform beta.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding serine 104/106 of human ER alpha. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Estrogen receptor α (ERα), a member of the steroid receptor superfamily, contains highly conserved DNA binding and ligand binding domains (1). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ERα regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery (2).Phosphorylation at multiple sites provides an important mechanism to regulate ERα activity (3-5). Ser104, 106, 118, and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serine residues plays an important role in regulating ERα activity. Ser118 may be the substrate of the transcription regulatory kinase CDK7 (5). Ser167 may be phosphorylated by p90RSK and Akt (4,6). According to the research literature, phosphorylation at Ser167 may confer tamoxifen resistance in breast cancer patients (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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