2511 Phospho-Estrogen Receptor α (Ser118) (16J4) Mouse mAb #2511

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产品详细参数如下>>>>

产品名称：Phospho-Estrogen Receptor α (Ser118) (16J4) Mouse mAb #2511
货号：2511
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
2511P	40 ul (4 western blots)	询价
2511S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IHC-P	H	Endogenous	66	Mouse IgG2b

Applications Key:  W=Western Blotting  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-Estrogen Receptor alpha (Ser118) (16J4) Mouse mAb detects endogenous levels of estrogen receptor alpha only when phosphorylated at serine 118. It does not cross-react with phosphorylated estrogen receptor beta.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser118 of human ER alpha.
抗体背景：

Estrogen receptor α (ERα), a member of the steroid receptor superfamily, contains highly conserved DNA binding and ligand binding domains (1). Through its estrogen-independent and estrogen-dependent activation domains (AF-1 and AF-2, respectively), ERα regulates transcription by recruiting coactivator proteins and interacting with general transcriptional machinery (2).Phosphorylation at multiple sites provides an important mechanism to regulate ERα activity (3-5). Ser104, 106, 118, and 167 are located in the amino-terminal transcription activation function domain AF-1, and phosphorylation of these serine residues plays an important role in regulating ERα activity. Ser118 may be the substrate of the transcription regulatory kinase CDK7 (5). Ser167 may be phosphorylated by p90RSK and Akt (4,6). According to the research literature, phosphorylation at Ser167 may confer tamoxifen resistance in breast cancer patients (4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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