2508 TrkA (14G6) Rabbit mAb #2508

"上海博耀生物销售TrkA (14G6) Rabbit mAb #2508，CST原装品质，价格优惠，订购TrkA (14G6) Rabbit mAb #2508，详情请咨询销售人

"上海博耀生物销售TrkA (14G6) Rabbit mAb #2508，CST原装品质，价格优惠，订购TrkA (14G6) Rabbit mAb #2508，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：TrkA (14G6) Rabbit mAb #2508
货号：2508
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2508P	40 ul (4 western blots)	询价
2508S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IHC-P	H	Endogenous	140	Rabbit IgG

Applications Key:  W=Western Blotting  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： TrkA (14G6) Rabbit mAb detects endogenous levels of total TrkA protein. This antibody does not cross-react with TrkB.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide surrounding Arg220 of human TrkA.
抗体背景：

The family of Trk receptor tyrosine kinases consists of TrkA, TrkB, and TrkC. While the sequence of these family members is highly conserved, they are activated by different neurotrophins: TrkA by NGF, TrkB by BDNF or NT4, and TrkC by NT3 (1). Neurotrophin signaling through these receptors regulates a number of physiological processes, such as cell survival, proliferation, neural development, and axon and dendrite growth and patterning (1). In the adult nervous system, the Trk receptors regulate synaptic strength and plasticity. TrkA regulates proliferation and is important for development and maturation of the nervous system (2). Phosphorylation at Tyr490 is required for Shc association and activation of the Ras-MAP kinase cascade (3,4). Residues Tyr674/675 lie within the catalytic domain, and phosphorylation at these sites reflects TrkA kinase activity (3-6). Point mutations, deletions, and chromosomal rearrangements (chimeras) cause ligand-independent receptor dimerization and activation of TrkA (7-10). TrkA is activated in many malignancies including breast, ovarian, prostate, and thyroid carcinomas (8-13). Research studies suggest that expression of TrkA in neuroblastomas may be a good prognostic marker as TrkA signals growth arrest and differentiation of cells originating from the neural crest (10).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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