2504 APC Antibody #2504

"上海博耀生物销售APC Antibody #2504，CST原装品质，价格优惠，订购APC Antibody #2504，详情请咨询销售人员！产品详细参数如下

"上海博耀生物销售APC Antibody #2504，CST原装品质，价格优惠，订购APC Antibody #2504，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：APC Antibody #2504
货号：2504
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2504S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H (M) (R) (Mk)	Endogenous	160 truncated APC in SW480 cells. 310 full-length APC.	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： APC Antibody detects endogenous levels of total APC protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the sequence of human APC. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The Adenomatous Polyposis Coli (APC) tumor suppressor gene is mutated in most familial and sporadic colorectal cancers and encodes a large cytoplasmic protein that is implicated in cell migration, cell adhesion, and proliferation (1). APC binds directly to microtubules and lack of APC leads to defective mitotic spindles and aneuploidy due to missegregation of chromosomes (2). APC is well characterized as a scaffolding protein, binds to β-catenin, and is involved in the regulation of its intracellular concentration. In the absence of a Wnt signal, GSK-3β phosphorylates all three members of the APC-β-catenin-axin complex and this phosphorylation of β-catenin creates a recognition site for ubiquitin, the signal for proteasome-mediated degradation. In the presence of a Wnt signal, dishevelled inactivates GSK-3β and β-catenin coordinates gene transcription of proteins important for the control of cell cycle progression and proliferation, such as cyclin D1 and c-Myc (3).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab103545/Anti-DDX53 antibody
Anti-Transthyretin转甲状腺素蛋白抗体
Anti-DOK6胞浆接头蛋白Dok6抗体
Anti-CEA/CD66e/CEACAM5癌胚抗原抗体
Anti-HMGA1/HMG-I/HMG-Y高迁移率族蛋白A1抗体
ab103722/Anti-FYTTD1 antibody
ab100970/Anti-GAG antibody
ab101508/Anti-CEP27 antibody
Anti-intestinal FABP/IFABP/FABP2肠型脂肪酸结合蛋白抗体
ab103699/Anti-DUS3L antibody
ab103227/Anti-FAM96B antibody
ab104266/Anti-ENPP7 antibody
ab102715/Anti-DRGX antibody
ab102972/Anti-DAK antibody
Anti-ATF3活化转录因子3抗体
ab102844/Anti-FUT3 antibody"
本页产品地址：http://www.geilan.com/sell/show-3242726.html