2494 MALT1 Antibody #2494

"上海博耀生物销售MALT1 Antibody #2494，CST原装品质，价格优惠，订购MALT1 Antibody #2494，详情请咨询销售人员！产品详细参数

"上海博耀生物销售MALT1 Antibody #2494，CST原装品质，价格优惠，订购MALT1 Antibody #2494，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：MALT1 Antibody #2494
货号：2494
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2494S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R	Endogenous	90	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： MALT1 Antibody detects endogenous levels of total MALT1 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy terminus of mouse and rat MALT1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Mucosa-associated lymphoid tissue translocation gene 1 (MALT1) is a paracaspase that is a critical mediator of T-cell receptor activation of NF-κB and may contribute to the progression of MALT lymphomas (1-4). It contains two immunoglobulin-like domains, an amino-terminal death domain and a carboxy-terminal caspase-like domain. Association of MALT1 with Bcl-10 and CARD11/Carma1 leads to activation of IKK and subsequent stimulation of NF-κB, resulting in increased proliferation and inhibition of apoptosis (5,6). A common translocation in MALT B-cell non-Hodgkin lymphomas t(11;18)(q21;q21) results in the fusion of the amino terminus of API2 (c-IAP2), a member of the inhibitor of apoptosis protein family, to the carboxy terminus of MALT1 (1,2). The API2-MALT1 fusion protein likely leads to deregulation of NF-κB, contributing to increased oncogenic potential (7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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