2490 eIF4A1 Antibody #2490

"上海博耀生物销售Phospho-IRS-1 (Ser302) (34C7) Rabbit mAb #2491，CST原装品质，价格优惠，订购Phospho-IRS-1 (Ser302) (34C7

"上海博耀生物销售Phospho-IRS-1 (Ser302) (34C7) Rabbit mAb #2491，CST原装品质，价格优惠，订购Phospho-IRS-1 (Ser302) (34C7) Rabbit mAb #2491，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-IRS-1 (Ser302) (34C7) Rabbit mAb #2491
货号：2491
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2491S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M	Endogenous	180	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-IRS-1 (Ser302) (37C7) Rabbit mAb detects endogenous levels of IRS-1 only when phosphorylated at Ser302.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser302 of mouse IRS-1 (equivalent to Ser307 of human IRS-1).
抗体背景：

Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase (1). IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin (2-4). IRS-1 also contains over 30 potential serine/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK (5) and IKK (6) while Ser789 is phosphorylated by SIK-2, a member of the AMPK family (7). The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636/639, respectively (8,9). Phosphorylation of IRS-1 at Ser1101 is mediated by PKCθ and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity (10).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-OPN/BSP骨桥蛋白抗体(分泌型磷蛋白1)
ab103454/Anti-GPSN2 antibody
ab103678/Anti-Adiponectin Receptor 2 antibody
Anti-bFGFR/FGFR1碱性成纤维细胞生长因子受体1抗体
ab102015/Anti-Angiopoietin 1 antibody
ab103257/Anti-CCDC6 antibody
Anti-RP1/DCDC4A视网膜色素变性蛋白1抗体
Anti-LAMR1(CT)层粘连蛋白受体1抗体（C端）
Anti-HIF-1 Alpha缺氧诱导因子1α 抗体HIF-1α
ab103249/Anti-CA13 antibody
ab10227/Anti-cardiac Troponin I antibody
Anti-B7H4B7-H4抗体
ab100/Anti-E2F1 antibody
ab103897/Anti-c-Myb antibody
ab10367/Anti-GRO gamma antibody
ab10257/Anti-FITC antibody"
本页产品地址：http://www.geilan.com/sell/show-3242703.html