2484 Phospho-PLCbeta3 (Ser1105) Antibody #2484

"上海博耀生物销售Phospho-PLCbeta3 (Ser1105) Antibody #2484，CST原装品质，价格优惠，订购Phospho-PLCbeta3 (Ser1105) Antibo

"上海博耀生物销售Phospho-PLCbeta3 (Ser1105) Antibody #2484，CST原装品质，价格优惠，订购Phospho-PLCbeta3 (Ser1105) Antibody #2484，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-PLCbeta3 (Ser1105) Antibody #2484
货号：2484
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2484S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H Mk	Endogenous	150	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-PLCbeta3 (Ser1105) Antibody detects endogenous levels of PLCbeta3 only when phosphorylated at serine 1105. The antibody does not cross-react with phosphorylated PLCbeta1, PLCbeta2, PLCbeta4 or other PLCs.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding top residues surrounding Ser1105 of human PLCbeta3. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Phosphoinositide-specific phospholipase C (PLC) plays a significant role in transmembrane signaling. In response to extracellular stimuli such as hormones, growth factors and neurotransmitters, PLC hydrolyzes phosphatidylinositol 4,5-bisphosphate (PIP2) to generate two secondary messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG) (1). At least four families of PLCs have been identified: PLCβ, PLCγ, PLCδ and PLCε. The PLCβ subfamily includes four members, PLCβ1-4. All four members of the subfamily are activated by α- or β-γ-subunits of the heterotrimeric G-proteins (2,3).Phosphorylation is one of the key mechanisms that regulates the activity of PLC. Phosphorylation of Ser1105 by PKA or PKC inhibits PLCβ3 activity (4,5). Ser537 of PLCβ3 is phosphorylated by CaMKII, and this phosphorylation may contribute to the basal activity of PLCβ3. PLCγ is activated by both receptor and nonreceptor tyrosine kinases (6).PLCγ forms a complex with EGF and PDGF receptors, which leads to the phosphorylation of PLCγ at Tyr771, 783 and 1245 (7). Phosphorylation by Syk at Tyr783 activates the enzymatic activity of PLCγ1 (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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