2464 PTCH2 (L849) Antibody #2464

"上海博耀生物销售PTCH2 (L849) Antibody #2464，CST原装品质，价格优惠，订购PTCH2 (L849) Antibody #2464，详情请咨询销售人员

"上海博耀生物销售PTCH2 (L849) Antibody #2464，CST原装品质，价格优惠，订购PTCH2 (L849) Antibody #2464，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：PTCH2 (L849) Antibody #2464
货号：2464
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2464S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H	Transfected Only	130 kDa	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： PTCH2 (L849) Antibody detects transfected levels of PTCH2 protein. It does not recognize transfected levels of human PTCH1. This antibody also cross-reacts with an unidentified protein at 55 kDa. 
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a region (predicted to be extracellular) surrounding residue Leu849 of human PTCH2. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Patched1 and 2 (PTCH1 and PTCH2) are twelve-pass transmembrane proteins that function as the receiving receptors for members of the Hedgehog family of proteins (1-4). In the absence of Hedgehog proteins, PTCH suppresses the otherwise constitutively active signaling receptor Smoothened (Smo) so that the Hedgehog signaling pathway is in the off state (5,6). Deactivating mutations that impair the ability of PTCH1 to suppress Smo are frequently found in patients with nevoid basal cell carcinoma syndrome (7,8). PTCH proteins have a sterol-sensing domain (SSD) also found in several proteins that function in cholesterol homeostasis, such as HMGCR (3-hydroxy-3-methylglutaryl coenzyme A-reductase) and SCAP (sterol regulatory element-binding protein-cleavage activating protein). However, the role of the SSD in Patched proteins is not clear (9,10).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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