2452 APP Antibody #2452

"上海博耀生物销售APP Antibody #2452，CST原装品质，价格优惠，订购APP Antibody #2452，详情请咨询销售人员！产品详细参数如下

"上海博耀生物销售APP Antibody #2452，CST原装品质，价格优惠，订购APP Antibody #2452，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：APP Antibody #2452
货号：2452
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2452S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IF-IC	H M R Mk	Endogenous	100 to 140	Rabbit

Applications Key:  W=Western Blotting  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： APP Antibody detects endogenous levels of several isoforms of both mature and immature amyloid beta (A4) precursor protein, including APP695, APP770 and APP751.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Thr668 of human APP695. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Amyloid β (Aβ) precursor protein (APP) is a 100-140 kDa transmembrane glycoprotein that exists as several isoforms (1). The amino acid sequence of APP contains the amyloid domain, which can be released by a two-step proteolytic cleavage (1). The extracellular deposition and accumulation of the released Aβ fragments form the main components of amyloid plaques in Alzheimer's disease (AD) (1). APP can be phosphorylated at several sites, which may affect the proteolytic processing and secretion of this protein (2-5). Phosphorylation at Thr668 (a position corresponding to the APP695 isoform) by cyclin-dependent kinase is cell-cycle dependent and peaks during G2/M phase (4). APP phosphorylated at Thr668 exists in adult rat brain and correlates with cultured neuronal differentiation (5,6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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