产品简介
"上海博耀生物销售PDI Antibody #2446,CST原装品质,价格优惠,订购PDI Antibody #2446,详情请咨询销售人员!产品详细参数如下
产品说明
"上海博耀生物销售
PDI Antibody #2446,CST原装品质,价格优惠,订购
PDI Antibody #2446,详情请咨询销售人员!
产品详细参数如下>>>>
产品名称:PDI Antibody #2446
货号:2446
品牌:CST(cell signaling)
抗体来源:Rabbit
克隆类型:
Polyclonal
规格:
| No. |
Size |
Price |
| 2446S |
100 ul (10 western blots) |
询价 |
抗体应用:
| Applications |
Reactivity |
Sensitivity |
MW (kDa) |
Source |
| W IHC-P IF-IC |
H M R Mk |
Endogenous |
57 |
Rabbit |
Applications Key:
W=Western Blotting
IHC-P=Immunohistochemistry (Paraffin)
IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:
H=Human
M=Mouse
R=Rat
Mk=Mon
key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度:
PDI Antibody detects endogenous levels of total PDI protein.
来源及纯化方法:
Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro329 of human PDI. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景:
During their synthesis, secretory proteins translocate into the endoplasmic reticulum (ER) where they are post-translationally modified and properly folded. To reach their native conformation, many secretory proteins require the formation of intra- or inter-molecular disulfide bonds (1). This process is called oxidative protein folding. Protein disulfide isomerase (PDI) catalyzes the formation and isomerization of these disulfide bonds (2). Studies on mechanisms of oxidative folding suggest that molecular oxygen oxidizes the ER-protein Ero1, which in turn oxidizes PDI through disulfide exchange (3). This event is then followed by PDI-catalyzed disulfide bond formation in folding proteins (3).
关键词:CST,抗体,一抗{byao_back}{byao_back2}
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