2423 Notch4 (L5C5) Mouse mAb #2423

"上海博耀生物销售Notch4 (L5C5) Mouse mAb #2423，CST原装品质，价格优惠，订购Notch4 (L5C5) Mouse mAb #2423，详情请咨询销售

"上海博耀生物销售Notch4 (L5C5) Mouse mAb #2423，CST原装品质，价格优惠，订购Notch4 (L5C5) Mouse mAb #2423，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Notch4 (L5C5) Mouse mAb #2423
货号：2423
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
2423S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H	Transfected Only	80 cleaved. 230 full-length.	Mouse IgG1

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Notch4 (L5C5) Mouse mAb detects levels of the transfected intracellular region of human Notch4 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a recombinant protein consisting of the Ankyrin repeat domain of human Notch4.
抗体背景：

Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate (1). Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD) (2). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes (3-4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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