2420 Notch2 (8A1) Rabbit mAb #2420

"上海博耀生物销售Notch2 (8A1) Rabbit mAb #2420，CST原装品质，价格优惠，订购Notch2 (8A1) Rabbit mAb #2420，详情请咨询销售

"上海博耀生物销售Notch2 (8A1) Rabbit mAb #2420，CST原装品质，价格优惠，订购Notch2 (8A1) Rabbit mAb #2420，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Notch2 (8A1) Rabbit mAb #2420
货号：2420
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2420S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H	Endogenous	230, 300	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Notch2 (8A1) Rabbit mAb detects endogenous levels of total Notch2 protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a recombinant protein consisting of the heterodimerization domain of human Notch2.
抗体背景：

Notch proteins (Notch1-4) are a family of transmembrane receptors that play important roles in development and the determination of cell fate (1). Mature Notch receptors are processed and assembled as heterodimeric proteins, with each dimer comprised of a large extracellular ligand-binding domain, a single-pass transmembrane domain, and a smaller cytoplasmic subunit (Notch intracellular domain, NICD) (2). Binding of Notch receptors to ligands of the Delta-Serrate-Lag2 (DSL) family triggers heterodimer dissociation, exposing the receptors to proteolytic cleavages; these result in release of the NICD, which translocates to the nucleus and activates transcription of downstream target genes (3-4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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