2412 PA28γ Antibody #2412

"上海博耀生物销售PA28γ Antibody #2412，CST原装品质，价格优惠，订购PA28γ Antibody #2412，详情请咨询销售人员！产品详细参

"上海博耀生物销售PA28γ Antibody #2412，CST原装品质，价格优惠，订购PA28γ Antibody #2412，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：PA28γ Antibody #2412
货号：2412
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2412S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP IHC-P IF-IC	H M R Mk	Endogenous	30	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： PA28γ Antibody detects endogenous levels of total PA28γ.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp16 of human PA2γ. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. PA700, PA28, and PA200 are three major protein complexes that function as activators of the 20S proteasome. There are three evolutionarily conserved subunits of PA28: PA28α (PSME1), PA28β (PSME2), and PA28γ (PSME3) (1,2). PA28α and PA28β form a heteroheptameric complex and function by binding to the 20S complex at its opening site(s). The PA28α/β complex is present throughout the cell and participates in MHC class I antigen presentation by promoting the generation of antigenic peptides from foreign proteins (2). PA28γ exists in the form of a homoheptamer and is mainly located in the nucleus. The PA28γ complex exerts its function by binding and guiding specific nuclear target proteins to the 20S proteasome for further degradation (3,4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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