2407 p14 ARF (4C6/4) Mouse mAb #2407

"上海博耀生物销售p14 ARF (4C6/4) Mouse mAb #2407，CST原装品质，价格优惠，订购p14 ARF (4C6/4) Mouse mAb #2407，详情请咨询

"上海博耀生物销售p14 ARF (4C6/4) Mouse mAb #2407，CST原装品质，价格优惠，订购p14 ARF (4C6/4) Mouse mAb #2407，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：p14 ARF (4C6/4) Mouse mAb #2407
货号：2407
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
2407S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IHC-P	H	Endogenous	14	Mouse IgG2a

Applications Key:  W=Western Blotting  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： p14 ARF (4C6/4) Mouse mAb detects endogenous levels of total p14 ARF protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a recombinant His-tagged p14 ARF protein.
抗体背景：

Human p14 ARF (p19 ARF in mouse) is a pro-apoptotic cell cycle regulator frequently inactive in human tumors (1). Basal expression of p14 ARF is low in most cell types, but accumulation of this protein occurs in response to oncogene expression (2,3). Increased p14 ARF levels facilitate MDM2 degradation, leading to increased p53 protein levels and subsequent cell cycle arrest and/or apoptosis (4). While most p14 ARF signaling has traditionally thought to be p53-dependent, more recent reports have described p53-independent p14 ARF signaling leading to cell cycle arrest and apoptosis (5,6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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