2402 HSP27 (G31) Mouse mAb #2402

"上海博耀生物销售HSP27 (G31) Mouse mAb #2402，CST原装品质，价格优惠，订购HSP27 (G31) Mouse mAb #2402，详情请咨询销售人员

"上海博耀生物销售HSP27 (G31) Mouse mAb #2402，CST原装品质，价格优惠，订购HSP27 (G31) Mouse mAb #2402，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：HSP27 (G31) Mouse mAb #2402
货号：2402
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
2402S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IHC-P IF-IC	H Mk	Endogenous	27	Mouse IgG1

Applications Key:  W=Western Blotting  IHC-P=Immunohistochemistry (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： HSP27 (G31) Mouse mAb detects endogenous levels of total HSP27 protein. The antibody does not cross-react with other heat shock proteins.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with full length HSP27 protein.
抗体背景：

Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small HSPs, HSP27 is regulated at both the transcriptional and posttranslational levels (1). In response to stress, the HSP27 expression increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is phosphorylated at Ser15, Ser78, and Ser82 by MAPKAPK-2 as a result of the activation of the p38 MAP kinase pathway (2,3). Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers (4). It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polymerization and reorganization (5,6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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