2400 Synip (C51G6) Rabbit mAb #2400

"上海博耀生物销售Synip (C51G6) Rabbit mAb #2400，CST原装品质，价格优惠，订购Synip (C51G6) Rabbit mAb #2400，详情请咨询销

"上海博耀生物销售Synip (C51G6) Rabbit mAb #2400，CST原装品质，价格优惠，订购Synip (C51G6) Rabbit mAb #2400，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Synip (C51G6) Rabbit mAb #2400
货号：2400
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Synip
规格：

No.	Size	Price
2400S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R	Endogenous	62	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Synip (C51G6) Rabbit mAb detects endogenous levels of total Synip protein.
来源及纯化方法： Synip (C51G6) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to the sequence of human Synip.
抗体背景：

Insulin binds to and activates its receptor and initiates a signaling cascade that eventually induces the translocation of the Glut4 glucose transporter from its intracellular locations to the plasma membrane. Initiating this pathway facilitates glucose uptake in fat and skeletal muscle cells (1). Synip and Syntaxin 4 are two proteins thought to be involved in the recruitment of Glut4-containing vesicles to plasma membrane (2,3). Synip associates with Syntaxin 4 when insulin is absent. Insulin signaling triggers the dissociation of the two proteins and allows Syntaxin 4 to complex with VAMP2, which is essential for Glut4 translocation to plasma membrane (2-4). Overexpression of a dominant-negative form of Synip prevents Glut4 from translocating to plasma membrane in response to insulin stimulation (3). Synip together with Syntaxin 4, therefore, regulates Glut 4 transport to plasma membrane.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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