2399 Rap1A/Rap1B (26B4) Rabbit mAb #2399

"上海博耀生物销售Rap1A/Rap1B (26B4) Rabbit mAb #2399，CST原装品质，价格优惠，订购Rap1A/Rap1B (26B4) Rabbit mAb #2399，详

"上海博耀生物销售Rap1A/Rap1B (26B4) Rabbit mAb #2399，CST原装品质，价格优惠，订购Rap1A/Rap1B (26B4) Rabbit mAb #2399，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Rap1A/Rap1B (26B4) Rabbit mAb #2399
货号：2399
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2399S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R Mk B	Endogenous	21	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  B=Bovine
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Rap1 (26B4) Rabbit mAb detects endogenous levels of total Rap1A and Rap1B protein.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with synthetic peptides corresponding to the carboxy-terminal half of human Rap1A/RAP1B.
抗体背景：

Rap1 and Rap2 belong to the Ras subfamily of small GTPases and are activated by a wide variety of stimuli through integrins, receptor tyrosine kinases (RTKs), G-protein coupled receptors (GPCR), death domain associated receptors (DD-R) and ion channels (1,2). Like other small GTPases, Rap activity is stimulated by guanine nucleotide exchange factors (GEF) and inactivated by GTPase activating proteins (GAP). A wide variety of Rap GEFs have been identified: C3G connects Rap1 with RTKs through adaptor proteins such as Crk, Epacs (or cAMP-GEFs) transmit signals from cAMP, and CD-GEFs (or CalDAG-GEFs) convey signals from either or both Ca2+ and DAG (1). Rap1 primarily regulates multiple integrin-dependent processes such as morphogenesis, cell-cell adhesion, hematopoiesis, leukocyte migration and tumor invasion (1,2). Rap1 may also regulate proliferation, differentiation and survival through downstream effectors including B-Raf, PI3K, RalGEF and phospholipases (PLCs) (1-4). Rap1 and Rap2 are not fuctionally redundant as they perform overlapping but distinct functions (5). Recent research indicates that Rap2 regulates Dsh subcellular localization and is required for Wnt signaling in early development (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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