2395 PDE5 Antibody #2395

"上海博耀生物销售PDE5 Antibody #2395，CST原装品质，价格优惠，订购PDE5 Antibody #2395，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售PDE5 Antibody #2395，CST原装品质，价格优惠，订购PDE5 Antibody #2395，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：PDE5 Antibody #2395
货号：2395
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2395S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H M	Endogenous	100	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： PDE5 Antibody detects endogenous levels of total PDE5 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to the carboxy-terminal sequence of human PDE5. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The superfamily of phosphodiesterases (PDEs) catalyses the hydrolysis of 3',5'-cyclic nucleotides into the corresponding nucleotide 5'-monophosphates. PDE5 is a cGMP-specific enzyme that contains two cGMP binding sites in its amino-terminal regulatory domain (1). Elevation of cGMP levels causes activation of PKG, which phosphorylates PDE5 at Ser102 (2). Phosphorylation of PDE5 stimulates its enzymatic activity and enhances cGMP binding affinity in the regulatory domain, leading to a decrease in intracellular cGMP levels (3,4).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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