2390 IRS-1 (59G8) Rabbit mAb #2390

"上海博耀生物销售IRS-1 (59G8) Rabbit mAb #2390，CST原装品质，价格优惠，订购IRS-1 (59G8) Rabbit mAb #2390，详情请咨询销售

"上海博耀生物销售IRS-1 (59G8) Rabbit mAb #2390，CST原装品质，价格优惠，订购IRS-1 (59G8) Rabbit mAb #2390，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：IRS-1 (59G8) Rabbit mAb #2390
货号：2390
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2390S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W	H M R (Pg)	Endogenous	180	Rabbit IgG

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat  Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： IRS-1 (59G8) Rabbit mAb detects endogenous levels of total IRS-1 protein. The antibody does not cross-react with IRS-2.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence surrounding Ser307 of human IRS-1.
抗体背景：

Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase (1). IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin (2-4). IRS-1 also contains over 30 potential serine/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK (5) and IKK (6) while Ser789 is phosphorylated by SIK-2, a member of the AMPK family (7). The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636/639, respectively (8,9). Phosphorylation of IRS-1 at Ser1101 is mediated by PKCθ and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity (10).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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