2389 Phospho-IRS-1 (Ser789) Antibody #2389

"上海博耀生物销售Phospho-IRS-1 (Ser789) Antibody #2389，CST原装品质，价格优惠，订购Phospho-IRS-1 (Ser789) Antibody #2389

"上海博耀生物销售Phospho-IRS-1 (Ser789) Antibody #2389，CST原装品质，价格优惠，订购Phospho-IRS-1 (Ser789) Antibody #2389，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-IRS-1 (Ser789) Antibody #2389
货号：2389
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2389S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	R (M)	Transfected Only	180	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-IRS-1 (Ser789) Antibody detects transfected IRS-1 only when phosphorylated at serine 789. This antibody does not cross-react with related phospho-proteins.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser789 of mouse IRS-1 (equivalent to Ser794 of human IRS-1). Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase (1). IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin (2-4). IRS-1 also contains over 30 potential serine/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK (5) and IKK (6) while Ser789 is phosphorylated by SIK-2, a member of the AMPK family (7). The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636/639, respectively (8,9). Phosphorylation of IRS-1 at Ser1101 is mediated by PKCθ and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity (10).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab103116/Anti-CA7 antibody
Anti-β-caseinβ-酪蛋白抗体
Anti-PCDHGA2原钙粘蛋白γA2抗体
Anti-TNR/Tenascin R腱糖蛋白R抗体
Anti-P21/CDKN1Ap21蛋白抗体
ab101368/Anti-Guanylyl Cyclase alpha 1 antibody
ab103980/Anti-Gasdermin like antibody
Anti-CRF/CRH促肾上腺皮质激素释放因子抗体
Anti-HLA G(C-terminal)人类白细胞抗原G抗体（C端）
Anti-Nrf2核因子2相关因子2抗体
ab103212/Anti-C1orf38 antibody
Anti-Calcitonin/CGRP1降钙素抗体
ab102644/Anti-COQ5 antibody
Anti-PCDHGA12原钙粘蛋白γA12抗体
ab103308/Anti-DDX6 antibody
ab103894/Anti-CXorf66 antibody"
本页产品地址：http://www.geilan.com/sell/show-3242514.html