2385 Phospho-IRS-1 (Ser1101) Antibody #2385

"上海博耀生物销售Phospho-IRS-1 (Ser1101) Antibody #2385，CST原装品质，价格优惠，订购Phospho-IRS-1 (Ser1101) Antibody #23

"上海博耀生物销售Phospho-IRS-1 (Ser1101) Antibody #2385，CST原装品质，价格优惠，订购Phospho-IRS-1 (Ser1101) Antibody #2385，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-IRS-1 (Ser1101) Antibody #2385
货号：2385
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2385S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R	Endogenous	180	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-IRS-1 (Ser1101) Antibody detects endogenous IRS-1 protein only when phosphorylated at serine 1101. The antibody cross-reacts with IRS-2. US Patent No. 7,731,964 and foreign equivalents assigned to Cell Signaling Technology, Inc.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser1101 of human IRS-1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Insulin receptor substrate 1 (IRS-1) is one of the major substrates of the insulin receptor kinase (1). IRS-1 contains multiple tyrosine phosphorylation motifs that serve as docking sites for SH2-domain containing proteins that mediate the metabolic and growth-promoting functions of insulin (2-4). IRS-1 also contains over 30 potential serine/threonine phosphorylation sites. Ser307 of IRS-1 is phosphorylated by JNK (5) and IKK (6) while Ser789 is phosphorylated by SIK-2, a member of the AMPK family (7). The PKC and mTOR pathways mediate phosphorylation of IRS-1 at Ser612 and Ser636/639, respectively (8,9). Phosphorylation of IRS-1 at Ser1101 is mediated by PKCθ and results in an inhibition of insulin signaling in the cell, suggesting a potential mechanism for insulin resistance in some models of obesity (10).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-LH促黄体生成素抗体
ab103733/Anti-C1orf94 antibody
Anti-TTF-2甲状腺转录因子-2抗体
Anti-Calcitonin/CGRP1降钙素抗体
ab101671/Anti-ACSM2A antibody
Anti-Resistin抵抗素抗体
ab102816/Anti-GSTA3 antibody
ab102755/Anti-CSPP1 antibody
ab100918/Anti-FBP17 antibody
Anti-MCSF/M-CSF巨噬细胞克隆刺激因子抗体
ab10397/Anti-CCR5 antibody
Anti-PCDH11Y原钙粘附蛋白11Y抗体
ab104292/Anti-Epoxide hydrolase antibody
ab101984/Anti-Ancient ubiquitous protein 1 antibody
ab10402/Anti-CXCR3 antibody
ab100982/Anti-DGAT1 antibody"
本页产品地址：http://www.geilan.com/sell/show-3242508.html