2352 MEK1 (61B12) Mouse mAb #2352

"上海博耀生物销售MEK1 (61B12) Mouse mAb #2352，CST原装品质，价格优惠，订购MEK1 (61B12) Mouse mAb #2352，详情请咨询销售人

"上海博耀生物销售MEK1 (61B12) Mouse mAb #2352，CST原装品质，价格优惠，订购MEK1 (61B12) Mouse mAb #2352，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：MEK1 (61B12) Mouse mAb #2352
货号：2352
品牌：CST(cell signaling)
抗体来源：Mouse
克隆类型： Monoclonal
规格：

No.	Size	Price
2352S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M R Mk	Endogenous	45 kDa	Mouse IgG2a

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： MEK1 (61B2) Mouse mAb detects endogenous levels of total MEK1 protein. This antibody does not cross-react with MEK2 and other MAP kinase kinases.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with full length MEK1 proteins.
抗体背景：

MEK1 and MEK2, also called MAPK or Erk kinases, are dual-specificity protein kinases that function in a mitogen activated protein kinase cascade controlling cell growth and differentiation (1-3). Activation of MEK1 and MEK2 occurs through phosphorylation of two serine residues at positions 217 and 221, located in the activation loop of subdomain VIII, by Raf-like molecules. MEK1/2 is activated by a wide variety of growth factors and cytokines and also by membrane depolarization and calcium influx (1-4). Constitutively active forms of MEK1/2 are sufficient for the transformation of NIH/3T3 cells or the differentiation of PC-12 cells (4). MEK activates p44 and p42 MAP kinase by phosphorylating both threonine and tyrosine residues at sites located within the activation loop of kinase subdomain VIII.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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