2332 eEF2 Antibody #2332

"上海博耀生物销售eEF2 Antibody #2332，CST原装品质，价格优惠，订购eEF2 Antibody #2332，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售eEF2 Antibody #2332，CST原装品质，价格优惠，订购eEF2 Antibody #2332，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：eEF2 Antibody #2332
货号：2332
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2332S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IF-IC	H M R Mk Dm (Hm) (C)	Endogenous	95	Rabbit

Applications Key:  W=Western Blotting  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Hm=Hamster  Mk=Mon key  C=Chicken  Dm=D. melanogaster
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： eEF2 Antibody detects endogenous levels of total eEF2 independent of phosphorylation.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues at the amino-terminus of human eEF2. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Eukaryotic elongation factor 2 (eEF2) catalyzes the translocation of peptidyl-tRNA from the A site to the P site on the ribosome. It has been shown that phosphorylation of eEF2 at threonine 56 by eEF2 kinase inhibits its activity (1-4). eEF2 kinase is normally dependent on Ca2+ ions and calmodulin (5,6). eEF2 kinase can also be activated by PKA in response to elevated cAMP levels (7-9), which are generally increased in stress- or starvation-related conditions. A variety of treatments known to raise intracellular Ca2+ or cAMP levels have been shown to result in increased phosphorylation of eEF2, and thus to inhibit peptide-chain elongation. The inactive phosphorylated eEF2 can be converted to its active nonphosphorylated form by a protein phosphatase, most likely a form of protein phosphatase-2A (PP-2A). Insulin, which activates protein synthesis in a wide range of cell types, induces rapid dephosphorylation of eEF2 through mTOR signaling and may involve modulation of the activity of the PP-2A or the eEF2 kinase or both (10).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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