2290 PP2A B Subunit (100C1) Rabbit mAb #2290

"上海博耀生物销售PP2A B Subunit (100C1) Rabbit mAb #2290，CST原装品质，价格优惠，订购PP2A B Subunit (100C1) Rabbit mAb #

"上海博耀生物销售PP2A B Subunit (100C1) Rabbit mAb #2290，CST原装品质，价格优惠，订购PP2A B Subunit (100C1) Rabbit mAb #2290，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：PP2A B Subunit (100C1) Rabbit mAb #2290
货号：2290
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2290P	40 ul (4 western blots)	询价
2290S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P	H M R Mk Dm (C) (B) (Pg)	Endogenous	52	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  C=Chicken  Dm=D. melanogaster  B=Bovine  Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： PP2A B Subunit (100C1) Rabbit mAb detects endogenous levels of the PR55 PP2A B subunit (a isoform). The antibody may also recognize the b, g, and d isoforms of the PR55 PP2A B subunit. This antibody does not cross-react with the B-prime (PR61), B-prime-prime or B-prime-prime-prime families of PP2A B subunits.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human PP2A B subunit.
抗体背景：

Protein phosphatase type 2A (PP2A) is an essential protein serine/threonine phosphatase that is conserved in all eukaryotes. PP2A is a key enzyme within various signal transduction pathways as it regulates fundamental cellular activities such as DNA replication, transcription, translation, metabolism, cell cycle progression, cell division, apoptosis and development (1-3). The core enzyme consists of catalytic C and regulatory A (or PR65) subunits, with each subunit represented by α and β isoforms (1). Additional regulatory subunits belong to four different families of unrelated proteins. Both the B (or PR55) and B' regulatory protein families contain α, β, γ and δ isoforms, with the B' family also including an ε protein. B'' family proteins include PR72, PR130, PR59 and PR48 isoforms, while striatin (PR110) and SG2NA (PR93) are both members of the B''' regulatory protein family. These B subunits competitively bind to a shared binding site on the core A subunit (1). This variable array of holoenzyme components, particularly regulatory B subunits, allows PP2A to act in a diverse set of functions. PP2A function is regulated by expression, localization, holoenzyme composition and post-translational modification. Phosphorylation of PP2A at Tyr307 by Src occurs in response to EGF or insulin and results in a substantial reduction of PP2A activity (4). Reversible methylation on the carboxyl group of Leu309 of PP2A has been observed (5,6). Methylation alters the conformation of PP2A, as well as its localization and association with B regulatory subunits (6-8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab103001/Anti-Ephrin B3 antibody
ab101891/Anti-CATSPER1 antibody
ab103480/Anti-GPCR GPR17 antibody
Anti-MPO/c-ANCA髓过氧化物酶抗体
ab100933/Anti-BCNP antibody
ab103606/Anti-C3orf21 antibody
Anti-PEG10肝癌高表达基因抗体
Anti-NR2C/NMDAR2C谷氨酸受体2C抗体（N端）
ab104262/Anti-ATL3 antibody
Anti-GLUR谷胱甘肽还原酶抗体
Anti-Lysozyme溶菌酶抗体
Anti-Tau protein微管相关蛋白抗体
Anti-M2-PK/PKM2小鼠抗丙酮酸激酶-M2抗体
Anti-Adiponectin脂联素抗体
Anti-PCDHB12原钙粘蛋白β12抗体
ab102046/Anti-ERLEC1 antibody"
本页产品地址：http://www.geilan.com/sell/show-3242369.html