2286 LEF1 (C18A7) Rabbit mAb #2286

"上海博耀生物销售LEF1 (C18A7) Rabbit mAb #2286，CST原装品质，价格优惠，订购LEF1 (C18A7) Rabbit mAb #2286，详情请咨询销售

"上海博耀生物销售LEF1 (C18A7) Rabbit mAb #2286，CST原装品质，价格优惠，订购LEF1 (C18A7) Rabbit mAb #2286，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：LEF1 (C18A7) Rabbit mAb #2286
货号：2286
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2286S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP F	H M	Endogenous	25-58 kDa	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  F=Flow Cytometry
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： LEF1 (C18A7) Rabbit mAb detects endogenous level of total LEF1 proteins, including the dominant negative forms due to the usage of alternative promoter.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val282 of human LEF1.
抗体背景：

LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1), TCF3, and TCF4 (1). LEF1 and TCF1 were originally identified as important factors regulating early lymphoid development (2) and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling (3). LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers including colon cancer (4,5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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