2280 Raptor (24C12) Rabbit mAb #2280

"上海博耀生物销售Raptor (24C12) Rabbit mAb #2280，CST原装品质，价格优惠，订购Raptor (24C12) Rabbit mAb #2280，详情请咨询

"上海博耀生物销售Raptor (24C12) Rabbit mAb #2280，CST原装品质，价格优惠，订购Raptor (24C12) Rabbit mAb #2280，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Raptor (24C12) Rabbit mAb #2280
货号：2280
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Raptor
规格：

No.	Size	Price
2280P	40 ul (4 western blots)	询价
2280S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP	H M R Mk	Endogenous	150	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Raptor (24C12) Rabbit mAb detects endogenous levels of total Raptor protein.
来源及纯化方法： Raptor (24C12) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to the sequence of human Raptor.
抗体背景：

The regulatory associated protein of mTOR (Raptor) was identified as an mTOR binding partner that mediates mTOR signaling to downstream targets (1,2). Raptor binds to mTOR substrates, including 4E-BP1 and p70 S6 kinase, through their TOR signaling (TOS) motifs and is required for mTOR-mediated phosphorylation of these substrates (3,4). Binding of the FKBP12-rapamycin complex to mTOR inhibits the mTOR-raptor interaction, suggesting a mechanism for rapamycin's specific inhibition of mTOR signaling (5). This mTOR-raptor interaction and its regulation by nutrients and/or rapamycin is dependent on a protein called GβL (6). GβL is also part of the rapamycin-insensitive complex between mTOR and rictor (rapamycin-insensitive companion of mTOR), and may mediate rictor-mTOR signaling to downstream targets including PKCα (7). Furthermore, the rictor-mTOR complex has been identified as the previously elusive PDK2 responsible for the phosphorylation of Akt/PKB on Ser473, facilitating phosphorylation of Akt/PKB on Thr308 by PDK1 and required for the full activation of Akt/PKB (8).Recently raptor has been identified as a direct substrate of the AMP-activated protein kinase (AMPK) (9). AMPK phosphorylates raptor on Ser722/Ser792 (9). This phosphorylation is essential for inhibition of the raptor-containing mTOR complex 1 (mTORC1) and induces cell cycle arrest when cells are stressed for energy (9). These findings suggest that raptor is a critical switch that correlates cell cycle progression with energy status.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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