2267 RPA70 Antibody #2267

"上海博耀生物销售RPA70 Antibody #2267，CST原装品质，价格优惠，订购RPA70 Antibody #2267，详情请咨询销售人员！产品详细参数

"上海博耀生物销售RPA70 Antibody #2267，CST原装品质，价格优惠，订购RPA70 Antibody #2267，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：RPA70 Antibody #2267
货号：2267
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2267S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP IF-IC F	H R Mk	Endogenous	70	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry
Reactivity Key:  H=Human  R=Rat  Mk=Mon key
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： RPA70 antibody detects endogenous levels of total RPA70 subunit.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids near the amino terminus of human RPA70. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

RPA70 (HSSB, REPA1, RF-A, RP-A, p70) is a component of a heterotrimeric complex, composed of 70, 32/30 and 14 kDa subunits, collectively known as RPA. RPA is a single stranded DNA binding protein, whose DNA binding activity is believed to reside entirely in the 70 kDa subunit. The complex is required for almost all aspects of cellular DNA metabolism such as DNA replication (1-3), recombination, cell cycle and DNA damage checkpoints, and all major types of DNA repair including nucleotide excision, base excision, mismatch and double-strand break repairs (4-7). In response to genotoxic stress in eukaryotic cells, RPA has been shown to associate with the Rad9/Rad1/Hus1 (9-1-1) checkpoint complex (8). RPA is hyperphosphorylated upon DNA damage or replication stress by checkpoint kinases including ataxia telangiectasia mutated (ATM), ATM and Rad3-related (ATR), and DNA-dependent protein kinase (DNA-PK) (9-11). Hyperphosphorylation may alter RPA-DNA and RPA-protein interactions. In addition to the checkpoint partners, RPA interacts with a wide variety of protein partners, including proteins required for normal replication such as RCF, PCNA and Pol α, and also proteins involved in SV40 replication, such as DNA polymerase I and SV40 large T antigen (10,12).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab103733/Anti-C1orf94 antibody
Anti-PKA/PKAcat/PKACB蛋白激酶A抗体
Anti-CEA/CD66e/CEACAM5癌胚抗原抗体
ab102041/Anti-C1orf144 antibody
ab103669/Anti-C13orf15 antibody
ab101453/Anti-ESD antibody
ab100911/Anti-CD163 antibody
Anti-MMP-3基质金属蛋白酶3抗体
ab100804/Anti-DAP3 antibody
Anti-CYP450细胞色素P450单氧化酶抗体
ab103235/Anti-CHN 1 antibody
Anti-procollagen type IIAⅡ型胶原α1抗体
Anti-HSP70/HSPA1A热休克蛋白70抗体
Anti-DMBT1抑癌基因抗体
Anti-B7H4B7-H4抗体
ab100809/Anti-GIT2 antibody"
本页产品地址：http://www.geilan.com/sell/show-3242338.html