2266 PU.1 Antibody #2266

"上海博耀生物销售PU.1 Antibody #2266，CST原装品质，价格优惠，订购PU.1 Antibody #2266，详情请咨询销售人员！产品详细参数如

"上海博耀生物销售PU.1 Antibody #2266，CST原装品质，价格优惠，订购PU.1 Antibody #2266，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：PU.1 Antibody #2266
货号：2266
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2266S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP IHC-P IF-IC F ChIP	H M (Mk) (Pg)	Endogenous	42	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry  ChIP=Chromatin IP
Reactivity Key:  H=Human  M=Mouse  Mk=Mon key  Pg=Pig
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： This antibody detects endogenous levels of total PU.1 protein. The antibody does not cross react with other Ets family members.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to amino acids at the amino-terminus of human PU.1. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

PU.1 is a member of the Ets family of transcription factors and activates target genes through the purine-rich PU-box (1). PU.1 plays a pivotal role in the differentiation of myeloid cells and lymphocytes and is expressed in several hematopoietic cells including B lymphocytes, macrophages, neutrophils, mast cells, early erythroid cells and megakaryocytes (1,2). The concentration of PU.1 is critical for both the determination of hematopoietic cell lineage and the regulation of differentiation versus stem cell proliferation (3,4). In addition, PU.1 activity is influenced by phosphorylation and interactions with other hematopoietic transcription factors. Phosphorylation of PU.1 at Ser146 by CK2 promotes binding to IRF4 and synergistic activation through the immunoglobulin κ 3' enhancer (5). Treatment of pro-B cells with IL-3 leads to phosphorylation of PU.1 at Ser140, resulting in increased PU.1 activity and activation of the anti-apoptotic gene MCL-1 (6). GATA1 binding blocks PU.1 activity during erythroid cell development (7). Overexpression of PU.1 resulting from proviral insertion during Friend virus infection can induce erythroleukemia, while reduced expression has been associated with acute myeloid leukemia (8).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
ab103961/Anti-B9D2 antibody
ab102767/Anti-GPCR GPR65 antibody
Anti-LFABP/FABP-2肝脏型脂肪酸结合蛋白抗体
ab103896/Anti-ALDH1B1 antibody
Anti-PAX3配对盒基因3抗体
Anti-IGF I胰岛素样生长因子1抗体
Anti-14-3-3(Alpha/Beta/Gamma/Delta/Epsilon)14-3-3蛋白抗体
ab101892/Anti-CATSPER4 antibody
ab101575/Anti-GTPBP9 antibody
ab101582/Anti-C9orf114 antibody
Anti-Caspase-3(Active)活化半胱胺酸蛋白酶蛋白-3抗体
Anti-VEGFB血管内皮生长因子B
Anti-T4/L-Thyroxine甲状腺素T4抗体
Anti-PKB/AKT-1蛋白激酶B
ab103733/Anti-C1orf94 antibody
ab101929/Anti-Connexin 40 / GJA5 antibody"
本页产品地址：http://www.geilan.com/sell/show-3242337.html