2261 Phospho-(Ser)PKCSubstrateAntibody#2261

"上海博耀生物销售Phospho-(Ser)PKCSubstrateAntibody#2261，CST原装品质，价格优惠，订购Phospho-(Ser)PKCSubstrateAntibody#22

"上海博耀生物销售Phospho-(Ser)PKCSubstrateAntibody#2261，CST原装品质，价格优惠，订购Phospho-(Ser)PKCSubstrateAntibody#2261，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-(Ser)PKCSubstrateAntibody#2261
货号：2261
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：2261L

No.	Size	Price
2261S	200ul(10westernblots)	询价
600ul(30westernblots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	Source
WIPE-P	All	Endogenous	Rabbit

ApplicationsKey:  W=WesternBlotting  IP=Immunoprecipitation  E-P=ELISA(Peptide)
ReactivityKey:All=Allspeciesexpected
Speciescross-reactivityisdeterminedbywesternblot.
特异性/敏感度： Phospho-(Ser)PKCSubstrateAntibodydetectsendogenouslevelsofmanycellularproteinsonlywhenphosphorylatedatserineresiduessurroundedbyArgorLysatthe-2and+2positionsandahydrophobicresidueatthe+1position.Theantibodydoesnotcross-reactwithnonphosphorylatedserineresidues,withphospho-threonineinthesamemotif,orwithphospho-serineinothermotifs.(U.S.PatentNo's.:6,441,140;6,982,318;7,259,022;7,344,714;U.S.S.N.11,484,485;andallforeignequivalents.)
来源及纯化方法： Polyclonal antibodiesareproducedbyimmunizinganimalswithsyntheticphospho-PKCsubstratepeptides.AntibodiesarepurifiedbyproteinAandpeptideaffinitychromatography.
抗体背景： AlthoughproteinkinaseC(PKC)familymembersareinvolvedinanumberofsignaltransductionprocessesincludingsecretion,geneexpression,proliferation,andmusclecontraction(1,2),manyoftheirsubstratesremainunidentified.IsozymesofPKCaresubdividedintoconventionalPKCs(cPKC),novelPKCs(nPKC),andatypicalPKCs(aPKC).PKCα,βI,βII,andγisoformsbelongtothecPKCgroup(1).Whenactivated,cPKCisozymesphosphorylatesubstratescontainingSerorThr,withArgorLysatthe-3,-2,and+2positions,andahydrophobicaminoacidatposition+1(1-3).ToidentifypotentialPKCsubstrates,CellSignalingTechnologyhasdevelopedantibodiesthatrecognizethismotif.Phospho-(Ser)PKCSubstrate(D13C5/D47H10/D50E3)RabbitmAbisspecifictocPKCsubstratescontainingphospho-Ser.

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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