2251 FosB (5G4) Rabbit mAb #2251

FosB (5G4) Rabbit mAb #2251，CST原装品质，价格优惠，订购FosB (5G4) Rabbit mAb #2251，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：FosB (5G4) Rabbit mAb #2251
货号：2251
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2251S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P IF-IC F ChIP	H M R	Endogenous	38 FosB2 48 FosB	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry  ChIP=Chromatin IP
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： FosB (5G4) Rabbit mAb detects endogenous levels of total FosB protein (both FosB and FosB2 isoforms). The antibody does not cross-react with other Fos proteins, including c-fos, FRA1 and FRA2.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to the sequence of human FosB.
抗体背景：

The Fos family of nuclear oncogenes includes c-Fos, FosB, Fos-related antigen 1 (FRA1), and Fos-related antigen 2 (FRA2) (1). While most Fos proteins exist as a single isoform, the FosB protein exists as two isoforms: full-length FosB and a shorter form, FosB2 (Delta FosB), that lacks the carboxy-terminal 101 amino acids (1-3). The expression of Fos proteins is rapidly and transiently induced by a variety of extracellular stimuli including growth factors, cytokines, neurotransmitters, polypeptide hormones, and stress. Fos proteins dimerize with Jun proteins (c-Jun, JunB, and JunD) to form Activator Protein-1 (AP-1), a transcription factor that binds to TRE/AP-1 elements and activates transcription. Fos and Jun proteins contain the leucine-zipper motif that mediates dimerization and an adjacent basic domain that binds to DNA. The various Fos/Jun heterodimers differ in their ability to transactivate AP-1 dependent genes. In addition to increased expression, phosphorylation of Fos proteins by Erk kinases in response to extracellular stimuli may further increase transcriptional activity (4-6). Phosphorylation of c-Fos at Ser32 and Thr232 by Erk5 increases protein stability and nuclear localization (5). Phosphorylation of FRA1 at Ser252 and Ser265 by Erk1/2 increases protein stability and leads to overexpression of FRA1 in cancer cells (6). Following growth factor stimulation, expression of FosB and c-Fos in quiescent fibroblasts is immediate, but very short-lived, with protein levels dissipating after several hours (7). FRA1 and FRA2 expression persists longer, and appreciable levels can be detected in asynchronously growing cells (8). Deregulated expression of c-Fos, FosB, or FRA2 can result in neoplastic cellular transformation; however, Delta FosB lacks the ability to transform cells (2,3).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-IFN-β干扰素β抗体
ab101971/Anti-C18orf25 antibody
Anti-GSK-3 Beta (CT)葡萄糖合成激酶GSK-3β抗体
ab101748/Anti-BDNF antibody
ab103793/Anti-ELAC2 antibody
Anti-Nanog胚胎干细胞关键蛋白抗体
Anti-Neuropilin-2/NRP2神经纤毛蛋白2抗体
ab10409/Anti-EGF antibody
Anti-GRO Alpha/GRO-1/CXCL1生长调节致癌基因-1抗体GROa GROβ
Anti-CDK5周期素依赖性激酶5抗体
Anti-CDK8周期素依赖性激酶8抗体
Anti-OAT-1/SLC22A6阴离子转运蛋白-1抗体
Anti-ACTH (18-39)促肾上腺皮质激素ACTH(18-39)抗体
ab103590/Anti-ESM1 antibody
ab104170/Anti-ERp19 antibody
Anti-CD272/BTLAB和T淋巴细胞衰减蛋白抗体" />
本页产品地址：http://www.geilan.com/sell/show-3242322.html