2241 Phospho-HER2/ErbB2 (Tyr877) Antibody #2241

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产品详细参数如下>>>>

产品名称：Phospho-HER2/ErbB2 (Tyr877) Antibody #2241
货号：2241
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2241P	40 ul (4 western blots)	询价
2241S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H (M) (R)	Endogenous	185	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human  M=Mouse  R=Rat
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-HER2/ErbB2 (Tyr877) Antibody detects endogenous levels of ErbB2 only when phosphorylated at tyrosine 877. The antibody may cross-react with other ErbB family members (e.g., EGF receptor) when phosphorylated at their tyrosine residues.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Tyr877 of human ErbB2. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

The ErbB2 (HER2) proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity (1). While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members (2). Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers (3). Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase (4). ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy. Phosphorylation of the kinase domain residue Tyr877 of ErbB2 (homologous to Tyr416 of pp60c-Src) may be involved in regulating ErbB2 biological activity. The major autophosphorylation sites in ErbB2 are Tyr1248 and Tyr1221/1222; phosphorylation of these sites couples ErbB2 to the Ras-Raf-MAP kinase signal transduction pathway (1,5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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