2215 Phospho-S6 Ribosomal Protein (Ser240/244) Antibody #2215

"上海博耀生物销售Phospho-S6 Ribosomal Protein (Ser240/244) Antibody #2215，CST原装品质，价格优惠，订购Phospho-S6 Ribosom

"上海博耀生物销售Phospho-S6 Ribosomal Protein (Ser240/244) Antibody #2215，CST原装品质，价格优惠，订购Phospho-S6 Ribosomal Protein (Ser240/244) Antibody #2215，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Phospho-S6 Ribosomal Protein (Ser240/244) Antibody #2215
货号：2215
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2215S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IP	H M R Mk Z (C) (X)	Endogenous	32	Rabbit

Applications Key:  W=Western Blotting  IP=Immunoprecipitation
Reactivity Key:  H=Human  M=Mouse  R=Rat  Mk=Mon key  C=Chicken  X=Xenopus  Z=Zebrafish
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Phospho-S6 Ribosomal Protein (Ser240/244) Antibody detects endogenous levels of ribosomal protein S6 only when phosphorylated at serines 240 and 244. This antibody does not detect S6 ribosomal protein phosphorylated at other sites.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic phosphopeptide corresponding to residues surrounding Ser240 and Ser244 of human S6 ribosomal protein. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

One way that growth factors and mitogens effectively promote sustained cell growth and proliferation is by upregulating mRNA translation (1,2). Growth factors and mitogens induce the activation of p70 S6 kinase and the subsequent phosphorylation of the S6 ribosomal protein. Phosphorylation of S6 ribosomal protein correlates with an increase in translation of mRNA transcripts that contain an oligopyrimidine tract in their 5' untranslated regions (2). These particular mRNA transcripts (5'TOP) encode proteins involved in cell cycle progression, as well as ribosomal proteins and elongation factors necessary for translation (2,3). Important S6 ribosomal protein phosphorylation sites include several residues (Ser235, Ser236, Ser240, and Ser244) located within a small, carboxy-terminal region of the S6 protein (4,5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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