2203 TCF1 (C63D9) Rabbit mAb #2203

"上海博耀生物销售TCF1 (C63D9) Rabbit mAb #2203，CST原装品质，价格优惠，订购TCF1 (C63D9) Rabbit mAb #2203，详情请咨询销售

"上海博耀生物销售TCF1 (C63D9) Rabbit mAb #2203，CST原装品质，价格优惠，订购TCF1 (C63D9) Rabbit mAb #2203，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：TCF1 (C63D9) Rabbit mAb #2203
货号：2203
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Monoclonal
规格：

No.	Size	Price
2203P	40 ul (4 western blots)	询价
2203S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Isotype
W IP IHC-P IF-IC F	H M	Endogenous	48, 50 kDa	Rabbit IgG

Applications Key:  W=Western Blotting  IP=Immunoprecipitation  IHC-P=Immunohistochemistry (Paraffin)  IF-IC=Immunofluorescence (Immunocytochemistry)  F=Flow Cytometry
Reactivity Key:  H=Human  M=Mouse
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： TCF1 (C63D9) Rabbit mAb detects endogenous levels of total TCF1 protein. This antibody does not recognize the dominant negative isoforms of TCF1 lacking the amino-terminal β-catenin binding domain and does not cross-react with LEF1.
来源及纯化方法： Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to a region surrounding Pro95 of human TCF1 protein.
抗体背景：

LEF1 and TCF are members of the high mobility group (HMG) DNA binding protein family of transcription factors that consists of the following: Lymphoid Enhancer Factor 1 (LEF1), T Cell Factor 1 (TCF1), TCF3, and TCF4 (1). LEF1 and TCF1 were originally identified as important factors regulating early lymphoid development (2) and act downstream in Wnt signaling. LEF1 and TCF bind to Wnt response elements to provide docking sites for β-catenin, which translocates to the nucleus to promote the transcription of target genes upon activation of Wnt signaling (3). LEF1 and TCF are dynamically expressed during development and aberrant activation of the Wnt signaling pathway is involved in many types of cancers including colon cancer (4,5).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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