2186 CENP-A Antibody #2186

"上海博耀生物销售CENP-A Antibody #2186，CST原装品质，价格优惠，订购CENP-A Antibody #2186，详情请咨询销售人员！产品详细参

"上海博耀生物销售CENP-A Antibody #2186，CST原装品质，价格优惠，订购CENP-A Antibody #2186，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：CENP-A Antibody #2186
货号：2186
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2186P	40 ul (4 western blots)	询价
2186S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W IF-IC	H	Endogenous	17	Rabbit

Applications Key:  W=Western Blotting  IF-IC=Immunofluorescence (Immunocytochemistry)
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： CENP-A Antibody detects endogenous levels of total human CENP-A protein. This antibody does not cross-react with other histone proteins, including Histone H3.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to human CENP-A protein. Antibodies are purified by peptide affinity chromatography.
抗体背景：

Modulation of chromatin structure plays a critical role in the regulation of transcription and replication of the eukaryotic genome. The nucleosome, made up of four core histone proteins (H2A, H2B, H3, and H4), is the primary building block of chromatin. In addition to the growing number of post-translational histone modifications regulating chromatin structure, cells can also exchange canonical histones with variant histones that can directly or indirectly modulate chromatin structure (1). CENP-A, also known as the chromatin-associated protein CSE4 (capping-enzyme suppressor 4-p), is an essential histone H3 variant that replaces canonical histone H3 in centromeric heterochromatin (2). The greatest divergence between CENP-A and canonical histone H3 occurs in the amino-terminal tail of the protein, which binds linker DNA between nucleosomes and facilitates proper folding of centromeric heterochromatin (3). The amino-terminal tail of CENP-A is also required for recruitment of other centromeric proteins (CENP-C, hSMC1, hZW10), proper kinetochore assembly and chromosome segregation during mitosis (4). Additional sequence divergence in the histone fold domain is responsible for correct targeting of CENP-A to the centromere (5). Many of the functions of CENP-A are regulated by phosphorylation (6,7). Aurora A-dependent phosphorylation of CENP-A on Ser7 during prophase is required for proper targeting of Aurora B to the inner centromere in prometaphase, proper kinetochore/microtubule attachment and proper alignment of chromosomes during mitosis (6).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

相关产品：
Anti-SKP2/skp2 p45细胞S期激酶相关蛋白2抗体
Anti-VWF血管假性血友病因子/血管性血友病因子抗体
ab102590/Anti-FOXH1 antibody
ab1038/Anti-E. coli K99 pilus antibody
Anti-Oct-4/POU5F1胚胎干细胞关键蛋白抗体
Anti-JNK1/3氨基末端激酶1/3抗体
ab103165/Anti-FBP1 antibody
ab101095/Anti-beta 3 Adrenergic Receptor antibody
Anti-Caspase-6 (CT)半胱胺酸蛋白酶蛋白-6抗体（C端）
Anti-PVRL1/CD111/Nectin1脊髓灰质炎受体相关蛋白1抗体
ab102010/Anti-ERM / Etv5 antibody
ab10055/Anti-D-Dimer antibody
Anti-PARP多腺苷二磷酸多聚酶抗体/多聚ADP-核糖聚合酶1
ab101776/Anti-Calbindin antibody
Anti-NLGN4X神经元X连锁蛋白抗体（儿童自闭症相关蛋白）
Anti-Phospho-CBX5(Tyr37)磷酸化CBX5抗体"
本页产品地址：http://www.geilan.com/sell/show-3242239.html