2174 Smurf1 Antibody #2174

"上海博耀生物销售Smurf1 Antibody #2174，CST原装品质，价格优惠，订购Smurf1 Antibody #2174，详情请咨询销售人员！产品详细参

"上海博耀生物销售Smurf1 Antibody #2174，CST原装品质，价格优惠，订购Smurf1 Antibody #2174，详情请咨询销售人员！
产品详细参数如下>>>>

产品名称：Smurf1 Antibody #2174
货号：2174
品牌：CST(cell signaling)
抗体来源：Rabbit
克隆类型： Polyclonal
规格：

No.	Size	Price
2174S	100 ul (10 western blots)	询价

抗体应用：

Applications	Reactivity	Sensitivity	MW (kDa)	Source
W	H	Endogenous	81	Rabbit

Applications Key:  W=Western Blotting
Reactivity Key:  H=Human
Species cross-reactivity is determined by western blot. Species enclosed in parentheses are predicted to react based on sequence homology.
特异性/敏感度： Smurf1 Antibody detects endogenous levels of total Smurf1 protein.
来源及纯化方法： Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to a central region within human Smurf1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
抗体背景：

Bone morphogenetic proteins (BMPs) constitute a large family of signaling molecules that regulate a wide range of critical processes including morphogenesis, cell-fate determination, proliferation, differentiation, and apoptosis (1,2). BMP receptors are members of the TGF-β family of Ser/Thr kinase receptors. Ligand binding induces multimerization, autophosphorylation, and activation of these receptors (3-5). They subsequently phosphorylate Smad1 at Ser463 and Ser465 in the carboxy-terminal motif SSXS, as well as Smad5 and Smad8 at their corresponding sites. These phosphorylated Smads dimerize with the coactivating Smad4 and translocate to the nucleus, where they stimulate transcription of target genes (5).MAP kinases and CDKs 8 and 9 phosphorylate residues in the linker region of Smad1, including Ser206. The phosphorylation of Ser206 recruits Smurf1 to the linker region and leads to the degradation of Smad1 (6). Phosphorylation of this site also promotes Smad1 transcriptional action by recruiting YAP to the linker region (7).

关键词：CST，抗体，一抗{byao_back}{byao_back2}

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